Estrogen has been known to be one of the reasons for depression in women. It is for the same reason that depression begins with puberty. It remains throughout the reproductive period of the women. A constant observation has concluded that estrogen do initiates mood swings especially when their levels are high.

The levels of estrogen increases after puberty. So, the swinging in the mood is noticed when puberty is achieved.As the levels of estrogen decreases after the menopause postpartum is there. Although sometimes estrogen has been used as the antidepressant but still it is linked to the depression.

Estrogen And Depression:
Depression and estrogen are interlinked. This can be understood by the effect of estrogen on brain:

• Estrogen increases the levels of norepinephrine in the brain.
• It decreases the amount of Dopamine which is released from the brain.
• Estrogen has multiple effects on serotonin and also effects the levels of blood tryptophan( it is the amino acid which prepares serotonin).
• It directly effects the production of neurotrophic factors. These are known as the brain’s own cell fertilizer. These are directly involved in the mechanism of depression.
• Estrogen also increases the levels of endorphin in the brain as well as in the blood stream too.
• Estrogen also has some relation with melatonin which is the sleeping- regulating hormone.
• Estrogen is also linked with a neurosteroid which effects moods, like DHEA as the levels of this secretion also increases.

Thus, it can be concluded that Estrogen is directly or indirectly linked with mood swings.